Professional Experience

Associate Professor (Molecular Neurobiology). Middle East Technical University, Dept. of Biological Sciences, Ankara, TURKEY. (2022- ).

Assistant Professor (Molecular Neurobiology). Middle East Technical University, Dept. of Biological Sciences, Ankara, TURKEY. (2017-2022).  

Research Scientist (Molecular Neurobiology). Neural Development Section (Tessarollo Lab), Mouse Cancer Genetics Program, National Cancer Institute at Frederick, National Institutes of Health (In collaboration with US Army Medical Research Institute of Infectious Diseases (Bavari Lab)), Frederick, MD, USA. (2009-2017).  

Post-Doctoral Scholar (Molecular Neurobiology). University of California, Santa Barbara, CA, USA. Neuroscience Research Institute. (2008-2009).  

Research Assistant (Molecular Neurobiology). Univ. of California, Santa Barbara, CA, USA. Dept. of Molecular, Cellular and Developmental Biology (MCDB). (2003- 2008)

Research and Teaching Assistant. Mugla University, Faculty of Arts and Science, Biology Dept., TURKEY (2000-2003).

 

 Academic Degrees

Assoc. Prof. in Cell Biology

Turkish Higher Education Council                                                                           April 1, 2016

 Ph.D. in Molecular, Cellular and Developmental Biology.

University of California, Santa Barbara, CA, USA.                                                  2003-2008

Dissertation: “Mechanistic effects of pseudophosphorylation of 3-repeat and 4-repeat tau upon normal and pathological tau action: Implications for Alzheimer’s disease and related dementias”. Advisor: Dr. Stuart Feinstein.

 M.Sc. in Faculty of Arts and Science, Department of Biology.

Mugla University, Mugla, Turkey                                                                               2000-2003

 B.Sc. in Faculty of Education, Biology Department.

Selcuk University, Konya, Turkey                                                                             1996-2000

Selected Publications

  • J. Konstantinovic, E. Kiris, K. Kota, J. Kugelman-Tonos, M. Videnovic, L. H. Cazares, N. Terzic, T. Z. Verbic, M. Zlatovic, B. Andjelkovic, A. J. Duplantier, S. Bavari and B. A. Solaja (2018). New Steroidal 4-Aminoquinolines Antagonize BoNT/A in Mouse Embryonic Stem Cell Derived Motor Neurons in Post-intoxication Model. Journal of Medicinal Chemistry. 61(4):1595-1608. doi: 10.1021/acs.jmedchem.7b01710.
  • Y.C. Tsai, A. Kotiya, E. Kiris, M. Yang, S. Bavari, L. Tessarollo, G.A. Oyler, A.M. Weissman (2017). “The deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication”. Proceedings of the National Academy of Sciences. 114(26):E5158-E5166.
  • S. Puverel*, E. Kiris*, S. Singh, K.D. Klarmann, V. Coppola, J. Keller and L. Tessarollo (2016). “RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells”. Oncotarget, 2016 Dec 20;7(51):85109-85123. doi: 10.18632/oncotarget.13198. * Equal Contribution.
  • E. Kiris, J. C. Burnett, J. E. Nuss, L. M. Wanner, B. D. Peyser, H. T. Du, G. Y. Gomba, K. P. Kota, R. Panchal, R. Gussio, C.D. Kane, L. Tessarollo, and S. Bavari (2015). “Src family kinase inhibitors antagonize the toxicity of multiple serotypes of Botulinum neurotoxin in human embryonic stem cell-derived motor neurons”. Neurotoxicity Research, 27:384–398, DOI 10.1007/s12640-015-9526-z. *Selected as the cover illustration for the May 2015 edition of the journal.
  • E. Kiris, J. E. Nuss, S. M. Stanford, L. M. Wanner, L. Cazares, M. F. Maestre, H.T. Du, G. Y. Gomba, J. C. Burnett, R. Gussio, N. Bottini, R. Panchal, C. D. Kane, L. Tessarollo, and S. Bavari (2015). “Phosphatase inhibitors function as novel, broad spectrum Botulinum neurotoxin antagonists in mouse and human embryonic stem cell-derived motor neuron-based assays”. Plos One. 2015 Jun 10;10(6):e0129264. doi: 10.1371/journal.pone.0129264.
  • E. Kiris*, T. Wang*, S. Yanpallewar, S. Dorsey, J. Becker, S. Bavari, M.E. Palko, V. Coppola, and L. Tessarollo (2014). “TrkA in vivo function is negatively regulated by ubiquitination”. The Journal of Neuroscience, Mar 12;34(11):4090-8. doi: 10.1523/JNEUROSCI.4294-13.2014. *Equal Contribution. *Highlighted as a featured article by the journal.
  • E. Kiris, J. E. Nuss, J. C. Burnett, K. P. Kota, D. C. Koh, L. M. Wanner, E. Torres-Melendez, R. Gussio, L. Tessarollo, and S. Bavari (2011).Embryonic stem cell derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery”. Stem Cell Research, 6, pp 195-205, doi: 10.1016/j.scr.2011.01.002.
  • E. Kiris, D. Ventimiglia, M. R. Gaylord, M.E. Sargin, A. Altinok, K. Rose, B.S. Manjunath, M. A. Jordan, L. Wilson and S. C. Feinstein (2011). “Combinatorial Tau Pseudophosphorylation: Markedly different regulatory effects on microtubule assembly and dynamic instability than the sum of the individual parts”. Journal of Biological Chemistry, 286, 14257-14270, doi: 10.1074/jbc.M111.219311.

 

Book Chapter 

  • E. Kiris, D. Ventimiglia, S.C. Feinstein (2010). “Quantitative analysis of MAP-mediated regulation of microtubule dynamic instability in vitro-Focus on tau”. Methods in Cell Biology 95:481-503.

 

Peer-Review Activities

  •    Journal Reviewer for Stem Cells Translational Medicine (2015- ).
  •    Journal Reviewer for PLOS ONE (2013- ).
  •    Journal Reviewer for Toxins (2015- ). 
  •     Journal Reviewer for Journal of Biomolecular Screening (Journal name changed to SLAS Discovery) (2012- ).
  •     Journal Reviewer for Cancer Letters (2013- ).
  •     Journal Reviewer for Current Medicinal Chemistry (2016- )
  •     Journal Reviewer for Journal of Pharmacological and Toxicological Methods (2017- )
  •     Journal Reviewer for Alzheimer's & Dementia: Translational Research & Clinical Interventions (2017- )
  •     Journal Reviewer for BioFactors (2017- )
  •     Grant Proposal Reviewer for The Scientific and Technological Research Council of Turkey 

Selected Awards and Honors

  • Doctoral Student Travel Grant, 2008, University of California, Santa Barbara (UCSB).
  • Excellence in Neuroscience Award, 2007. Neuroscience Research Institute, UCSB.
  • Chang Award for Research in Biochemistry and Molecular Biology, 2007, UCSB  

 

Trainings and Specialized Courses

  • BioTech 55: Engineering with CRISPR, TALENs, & ZFNs Bethesda. The Foundation for Advanced Education in the Sciences at National Institutes of Health, Bethesda, MD, USA. Dec 5-9, 2016.
  • Induced Pluripotent Stem Cell Training, Stemgent. San Diego, CA, USA. Nov 9-11, 2010. (NIH Center for Regenerative Medicine (NCRM) covered the training expenses)
  • Human Embryonic Stem Cell Culture and Neural Differentiation Techniques. Stanford University Institute for Stem Cell Biology and Regenerative Medicine. Palo Alto, CA, USA. July13-17, 2009.

 

 Recent Research Funding

  • Role: Researcher, Career Re-Integration Fellowship, Funding Agency: TUBİTAK (#2232), Turkey. (2018-2010).
  • Role: Associate Investigator, Title:  Targeting Cellular Processes to Counter the Effects of BoNT Intoxication (AI101387), Funding Agency: National Institutes of Health, USA. (2012- Dec 2017).

 

Professional Memberships

  • Society for Neuroscience (2006-).
  • American Society for Cell Biology (2006-).  
  • American Association for the Advancement of Science (2008-).
  • International Society for Stem Cell Research (2010-).

 

 


Last Updated:
13/10/2022 - 09:46